Вот ответ с некоторым объяснением.
st = "Hey, you - what are you doing here!?"
# replace all the non alpha-numeric with space and then join.
new_string = ''.join([x.replace(x, ' ') if not x.isalnum() else x for x in st])
# output of new_string
'Hey you what are you doing here '
# str.split() will remove all the empty string if separator is not provided
new_list = new_string.split()
# output of new_list
['Hey', 'you', 'what', 'are', 'you', 'doing', 'here']
# we can join it to get a complete string without any non alpha-numeric character
' '.join(new_list)
# output
'Hey you what are you doing'
или в одну строку мы можем сделать так:
(''.join([x.replace(x, ' ') if not x.isalnum() else x for x in st])).split()
# output
['Hey', 'you', 'what', 'are', 'you', 'doing', 'here']
обновленный ответ