Попробуйте это
SELECT
user.userID, user.username,
SUM(IFNULL(a.commthumbs,0)+IFNULL(b.commthumbs,0)+IFNULL(c.commthumbs,0)+IFNULL(d.commthumbs,0)) AS 'commthumbs',
IFNULL(e.fixthumbs,0) AS 'fixthumbs'
FROM
user
LEFT JOIN (
SELECT
userID, SUM(IFNULL(gameCommThUp,0)-IFNULL(gameCommThDown,0)) AS 'commthumbs'
FROM
gamecomm
GROUP BY userID) a ON a.userID = user.userID
LEFT JOIN (
SELECT
userID, SUM(IFNULL(fixCommThUp,0)-IFNULL(fixCommThDown,0)) AS 'commthumbs'
FROM
fixcomm
GROUP BY userID) b ON b.userID = user.userID
LEFT JOIN (
SELECT
userID, SUM(IFNULL(replyCommThUp,0)-IFNULL(replyCommThDown,0)) AS 'commthumbs'
FROM gamereply
GROUP BY userID) c ON c.userID = user.userID
LEFT JOIN (
SELECT userID, SUM(IFNULL(fixReplyThUp,0)-IFNULL(fixReplyThDown,0)) AS 'commthumbs'
FROM fixreply
GROUP BY userID) d ON d.userID = user.userID
LEFT JOIN (
SELECT
userID, SUM(IFNULL(fixThUp,0)-IFNULL(fixThDown,0)) AS 'fixthumbs'
FROM
fix
GROUP BY userID) e ON e.userID = user.userID
WHERE user.userID = 2;