Это формат времени ISO8061 со смещением.
In [1]: x= '2018-02-28T20:40:28.079-0500'
In [2]: from dateutil.parser import parse
In [3]: parse(x)
Out[3]: datetime.datetime(2018, 2, 28, 20, 40, 28, 79000, tzinfo=tzoffset(None, -18000))
Для работы с ним в pandas Dataframe
In [7]: df = pd.DataFrame([x])
In [8]: df
Out[8]:
0
0 2018-02-28T20:40:28.079-0500
In [9]: df[0]
Out[9]:
0 2018-02-28T20:40:28.079-0500
Name: 0, dtype: object
In [10]: df[0].apply(parse)
Out[10]:
0 2018-02-28 20:40:28.079000-05:00
Name: 0, dtype: datetime64[ns, tzoffset(None, -18000)]