Вот решение с использованием XML Linq.
using System;
using System.Collections.Generic;
using System.Linq;
using System.Text;
using System.Xml;
using System.Xml.Linq;
namespace ConsoleApplication1
{
class Program
{
const string FILENAME = @"c:\temp\test.xml";
static void Main(string[] args)
{
XDocument doc = XDocument.Load(FILENAME);
XElement UUID = doc.Descendants().Where(x => x.Name.LocalName == "UUID").FirstOrDefault();
UUID.SetValue("new value");
}
}
}