import re
import pandas as pd
df=pd.DataFrame({'Description':['This is my mobile number 213 321 32111',
'another number 123 321 321',
'Hi, Shared accommodation is available in Lombard-IL. Single bed room and I preferred Veggie only. Please reach 630 828 3324 if any one interested. Thanks, Mohan']})
for i in range (len(df['Description'])):
print(re.sub(" \d+", " ",df.loc[i,"Description"]))
Этот код будет игнорировать все цифры из вашего описания.