Это похоже на работу.
from openpyxl import load_workbook
import pandas as pd
wb = load_workbook(filename = 'C:\\your_path\\Book1.xlsx')
sheet_names = wb.get_sheet_names()
name = sheet_names[0]
sheet_ranges = wb[name]
df = pd.DataFrame(sheet_ranges.values)
df
Результат:
0 1 2 3 4
0 field1 field2 field3 field4 field5
1 1 =A2*10 =B2*10 =C2*10 =D2*10
2 1 =A3*10 =B3*10 =C3*10 =D3*10
3 1 =A4*10 =B4*10 =C4*10 =D4*10