s = "8,5,,1,4,7,,,,7,,1,9,3,6,,,8,6,3,9,,2,5,4,,,,,3,2,,,7,4,1,1,,4,,6,9,,5,,,,5,,,1,,6,3,,,6,5,,,,7,4,,1,7,6,,,,8,,5,,,7,1,,3,9,"
s = re.sub('((?<=,)|^)(?=,|$)', '0', s)
print s
Печать:
8,5,0,1,4,7,0,0,0,7,0,1,9,3,6,0,0,8,6,3,9,0,2,5,4,0,0,0,0,3,2,0,0,7,4,1,1,0,4,0,6,9,0,5,0,0,0,5,0,0,1,0,6,3,0,0,6,5,0,0,0,7,4,0,1,7,6,0,0,0,8,0,5,0,0,7,1,0,3,9,0