df1= df[~(np.abs(df['col1']-df['col1'].mean()) <= 3*df['col1'].std())]
Рабочий пример:
import numpy as np
import pandas as pd
df = pd.DataFrame({'col1':[1,1,1,1,1,1,1,1,1,1,1,1,1,1,10]})
df1= df[~(np.abs(df['col1']-df['col1'].mean()) <= 3*df['col1'].std())]