Да, вы можете использовать функцию SetWinEventHook .
hEvent = SetWinEventHook(EVENT_SYSTEM_FOREGROUND ,
EVENT_SYSTEM_FOREGROUND , NULL,
WinEventProcCallback, 0, 0,
WINEVENT_OUTOFCONTEXT | WINEVENT_SKIPOWNPROCESS);
.......
VOID CALLBACK WinEventProcCallback ( HWINEVENTHOOK hWinEventHook, DWORD dwEvent, HWND hwnd, LONG idObject, LONG idChild, DWORD dwEventThread, DWORD dwmsEventTime)
{
/* your code here */
}