что-то вроде этого должно помочь
var oleDbConnection = new OleDbConnection(@"Provider=Microsoft.ACE.OLEDB.12.0;Data Source=|DataDirectory|\sample.accdb");
var oleDbCommand = oleDbConnection.CreateCommand();
oleDbCommand.CommandText = "insert into Table1 (Name, Photo) values (@name, @photo)";
oleDbCommand.Parameters.AddWithValue("@name", "MyName");
byte[] yourPhoto = GetYourPhotoFromSomewhere();
oleDbCommand.Parameters.AddWithValue("@photo", yourPhoto);
using (oleDbConnection)
{
oleDbConnection.Open();
oleDbCommand.ExecuteNonQuery();
}