Пример решения Барндона Моретца.
int x = 0;
int y = 0;
int width = 0;
int height = 0;
Point[] pesource = null;
GraphicsPath gpdest = new GraphicsPath();
source = new Bitmap(Image.FromFile(@"IMAGEPATH"));
//Your polygon
pesource = new Point[]
{
new Point(10,100),
new Point(30,150),
new Point(40,170),
new Point(60,120),
new Point(70,250),
new Point(40,300),
new Point(10,250),
new Point(30,150)
};
//Determine the destination size/position
x = source.Width;
y = source.Height;
foreach (var p in pesource)
{
if (p.X < x)
x = p.X;
if (p.X > width)
width = p.X;
if (p.Y < y)
y = p.Y;
if (p.Y > height)
height = p.Y;
}
height = height - y;
width = width - x;
gpdest.AddPolygon(pesource);
Matrix m = new Matrix(1, 0, 0, 1, -x, -y);
gpdest.Transform(m);
//Create the Bitmap
clipped = new Bitmap(width, height);
//Draw on the Bitmap
using (Graphics g = Graphics.FromImage(clipped))
{
GraphicsPath gpgdi = new GraphicsPath();
g.SetClip(gpdest);
g.DrawImage(source, -x, -y);
}