Конечно.
HTML:
What is your preferred vacation spot?<br>
<SELECT ID="my_select">
<OPTGROUP LABEL="OptGroup One." id="one">
<OPTION LABEL="Florida">Florida</OPTION>
<OPTION LABEL="Hawaii">Hawaii</OPTION>
<OPTION LABEL="Jersey">Jersey Shore</OPTION>
</OPTGROUP>
<OPTGROUP LABEL="OptGroup Two" id="two">
<OPTION LABEL="Paris">Paris</OPTION>
<OPTION LABEL="London">London</OPTION>
<OPTION LABEL="Florence">Florence</OPTION>
</OPTGROUP>
</SELECT>
JS:
$("#my_select").change(function(){
var selected = $("option:selected", this);
if(selected.parent()[0].id == "one"){
//OptGroup 1, do something here..
} else if(selected.parent()[0].id == "two"){
//OptGroup 2, do something here
}
});
Пример здесь: http://jsfiddle.net/pyG2v/