Этот пост , вероятно, отвечает на ваш вопрос.
Краткий пример кода
from difflib import SequenceMatcher
names_a = ["raju", "ramana", "seshu"]
names_b = ["vasu", "seshu", "ramana"]
similar = [SequenceMatcher(None, a, b).ratio() for a,b in zip(names_a, names_b)]
Выход:
In [7]: similar
Out[7]: [0.5, 0.0, 0.0]