Использование модуля pyodbc :
import pyodbc
MDB = 'c:/path/to/my.mdb'
DRV = '{Microsoft Access Driver (*.mdb)}'
PWD = 'my_password'
conn = pyodbc.connect('DRIVER=%s;DBQ=%s;PWD=%s' % (DRV,MDB,PWD))
c = conn.cursor()
c.execute("ALTER TABLE my_table ADD COLUMN my_column INTEGER;")
conn.commit()
c.close()
conn.close()
Редактирование:
Использование win32com.client
...
import win32com.client
conn = win32com.client.Dispatch(r'ADODB.Connection')
DSN = 'PROVIDER=Microsoft.Jet.OLEDB.4.0;DATA SOURCE=c:/path/to/my.mdb;'
conn.Open(DSN)
conn.Execute("ALTER TABLE my_table ADD COLUMN my_column INTEGER;")
conn.Close()